Fadrozole-Mediated Sex Reversal Induces PAX2+Undifferentiated Supporting Cells in Female Chicken Gonads
نویسندگان
چکیده
منابع مشابه
DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos.
Sex in birds is chomosomally based (ZZ male, ZW female), but the mechanism underlying sex determination remains unknown. An unresolved question is whether Z gene dosage plays a role in avian sex determination. DMRT1 is an avian Z-linked gene that shows higher expression in male gonads during embryogenesis and has been proposed as a putative testis-determining gene in birds. The Z-linkage of thi...
متن کاملHormonal sex reversal in a female.
The terms pseudo-hermaphroditism and hermaphroditism have been used in different senses by various authors and for this reason they were discarded by Wilkins (1950). He describes as 'intersexes' (hermaphrodites) those cases in which the sexual dimorphism is not due to a demonstrable endocrine abnormality, and as cases of 'sex reversal' those in which there is an endocrine abnormality. Hormonal ...
متن کاملFemale Meiotic Sex Chromosome Inactivation in Chicken
During meiotic prophase in male mammals, the heterologous X and Y chromosomes remain largely unsynapsed, and meiotic sex chromosome inactivation (MSCI) leads to formation of the transcriptionally silenced XY body. In birds, the heterogametic sex is female, carrying Z and W chromosomes (ZW), whereas males have the homogametic ZZ constitution. During chicken oogenesis, the heterologous ZW pair re...
متن کاملSex differentiation and mRNA expression of P450c17, P450arom and AMH in gonads of the chicken.
The present study was conducted to reveal effects of in ovo injection of nonsteroidal aromatase inhibitor (Fadrozole) or estradiol at day 3 of incubation on mRNA levels of P45017alphahydroxylase (P450c17), P450 aromatase (P450arom) and anti-Müllerian hormone (AMH) in the chicken gonads. The mRNA levels in the gonads at days 4-8 of incubation were assessed by in situ hybridization analysis using...
متن کاملGene Expression Profiling Reveals Potential Players of Left-Right Asymmetry in Female Chicken Gonads
Most female birds develop only a left ovary, whereas males develop bilateral testes. The mechanism underlying this process is still not completely understood. Here, we provide a comprehensive transcriptional analysis of female chicken gonads and identify novel candidate side-biased genes. RNA-Seq analysis was carried out on total RNA harvested from the left and right gonads on embryonic day 6 (...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2021
ISSN: 2472-1972
DOI: 10.1210/jendso/bvab048.1557